The FUS Breakapart probe consists of one 502kb probe labelled in green, situated distal to the FUS gene and covering markers SHGC-58827 and D16S2660, and three probes (189kb, 160kb and 96kb) labelled in red, situated proximal to the FUS gene and covering markers SHGC-110391 and D16S2933E.
The FUS (FUS RNA binding protein) gene at 16p11.2 is a member of the FET family of protein-encoding genes, closely-related to the EWSR1 (EWS RNA binding protein 1) gene1.
Recurrent rearrangements involving the FUS gene with a number of different partner genes have been reported in various types of neoplastic disease, notably soft tissue sarcomas and acute myeloid leukaemia. In some tumour types FUS and EWSR1 may replace each other as fusion partners2.
In soft tissue sarcoma, approximately 90% of cases of myxoid liposarcoma are characterised by the presence of a FUS-DDIT3 rearrangement arising from a t(12;16)(q13;p11) translocation3,4; the FUS-CREB3L1 and the FUS-CREB3L2 fusions, resulting from t(11;16) (p11;p11) and t(7;16)( q32-34;p11) translocations respectively are characteristic of low-grade fibromyxoid sarcoma5, whereas the t(12;16)(q13;p11) translocation resulting in a FUS-ATF1 fusion gene is seen in angiomatoid fibrous histiocytoma6.
This breakapart probe has been designed to allow detection of FUS rearrangements regardless of the partner gene involved.
Microscope image
In vitro diagnostic (IVD)
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Find certificate of analysis documentation for our CytoCell FISH probes
Our lab has been using a wide range of CytoCell FISH probes for a number of years, and have been increasing this range all the time. The probes have clear bright signals and show good reproducibility. CytoCell provides fast delivery of catalogue probes, and are very responsive when we have any queries or problems with their products.
Bridget Manasse
Addenbrookes Hospital, Cambridge University Hosiptals NHS Foundation Trust, UK
In our hands, CytoCell FISH probes have proven to be of the highest quality with bright, easy to interpret signals, thus providing confidence in our results. OGT's customer support is outstanding, as their staff are extremely knowledgeable and truly care about their customers and their customers’ needs.
Jennie Thurston
Director of Cytogenetics, Carolinas Pathology Group, USA
I first came across CytoCell FISH probes in a previous lab I worked in and I was struck by the quality of the products. Since this time, I have been recommending and introducing CytoCell probes across all application areas — now they are the primary FISH probes used in our lab. They have an excellent range of products and their ready-to-use reagent format saves considerable time.
Elizabeth Benner
Medical Technologist, University of Arizona Health Network, USA
We have been working with CytoCell fish probes for two decades because of their excellent clarity and intensity regardless of the size of the probe. It is so clear and simple to detect.
Dr. Marina Djurisic
Head of Laboratory of Medical Genetics, Mother and Child Health Care Institute of Serbia “Dr Vukan Cupic”, Serbia
The quality and consistency of CytoCell’s probes means I can trust the results, and my clients get their results in a timely manner.
Dr. Theresa C. Brown
Director, Cytogenetics Laboratory, Hayward Genetics Center, Tulane University School of Medicine, USA
It was very important for us to have more consistent results with our probes — easy-to-read bright signals and a range of vial sizes, which is much more cost-effective.
Janet Cowan, PhD
Director of the Cytogenetics Laboratory, Tufts Medical Center, USA
Not only do CytoCell offer an extensive range of high-quality FISH probes, the customer support is also excellent — providing fast access to all the probes I need. The probes are highly consistent with bright signals allowing easy scoring of results.
Dr. Eric Crawford
Senior Director, Genetics Associates Inc., USA
The quality and reproducibility of results using the CytoCell kit has been vital in accurately detecting co-deletions in our glioma investigations. We now have a cost-effective test that we can rely on that is also easy to use and interpret. We've been consistently impressed with this kit - not to mention the support offered by OGT's customer service, and have completely transitioned over to CytoCell probes.
Gavin Cuthbert, FRCPath
Head of Cancer Cytogenetics, Northern Genetics Servce, Newcastle, UK
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