The ROS1 Breakapart probe consists of a green 406kb probe and three red 175kb, 123kb and 184kb probes, which are positioned on each side of the ROS1 gene.
The receptor tyrosine kinase c-ros oncogene 1 (ROS1) is an orphan receptor tyrosine kinase of the insulin receptor family and is located at 6q221. ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in the differentiation of epididymal epithelium2.
ROS1 rearrangements have been reported to define a molecular subset of Non Small-Cell Lung Cancer (NSCLC)3. Rearrangements of ROS1 with fusion partners SLC34A2 (solute carrier family 34 (sodium phosphate), member 2)4 and CD74 (Cluster of Differentiation 74), have been shown to occur in less than 2% of patients with NSCLC3. Patients harbouring ROS1 rearrangement have been shown to respond to treatment with ALK/MET tyrosine kinase inhibitors, such as Xalkori® (crizotinib)5,6.
ROS1 rearrangements with the fusion partner GOPC (golgi-associated PDZ and coiled-coil motif containing) have also been implicated in Glioblastoma and Cholangiocarcinoma5,7. ROS1 Fusions activate the pSTAT3, PI3K/AKT/mTOR and the SHP-2 phosphatase pathways8,9.
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In vitro diagnostic (IVD)
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Find certificate of analysis documentation for our CytoCell FISH probes
Our lab has been using a wide range of CytoCell FISH probes for a number of years, and have been increasing this range all the time. The probes have clear bright signals and show good reproducibility. CytoCell provides fast delivery of catalogue probes, and are very responsive when we have any queries or problems with their products.
Bridget Manasse
Addenbrookes Hospital, Cambridge University Hosiptals NHS Foundation Trust, UK
In our hands, CytoCell FISH probes have proven to be of the highest quality with bright, easy to interpret signals, thus providing confidence in our results. OGT's customer support is outstanding, as their staff are extremely knowledgeable and truly care about their customers and their customers’ needs.
Jennie Thurston
Director of Cytogenetics, Carolinas Pathology Group, USA
I first came across CytoCell FISH probes in a previous lab I worked in and I was struck by the quality of the products. Since this time, I have been recommending and introducing CytoCell probes across all application areas — now they are the primary FISH probes used in our lab. They have an excellent range of products and their ready-to-use reagent format saves considerable time.
Elizabeth Benner
Medical Technologist, University of Arizona Health Network, USA
We have been working with CytoCell fish probes for two decades because of their excellent clarity and intensity regardless of the size of the probe. It is so clear and simple to detect.
Dr. Marina Djurisic
Head of Laboratory of Medical Genetics, Mother and Child Health Care Institute of Serbia “Dr Vukan Cupic”, Serbia
The quality and consistency of CytoCell’s probes means I can trust the results, and my clients get their results in a timely manner.
Dr. Theresa C. Brown
Director, Cytogenetics Laboratory, Hayward Genetics Center, Tulane University School of Medicine, USA
It was very important for us to have more consistent results with our probes — easy-to-read bright signals and a range of vial sizes, which is much more cost-effective.
Janet Cowan, PhD
Director of the Cytogenetics Laboratory, Tufts Medical Center, USA
Not only do CytoCell offer an extensive range of high-quality FISH probes, the customer support is also excellent — providing fast access to all the probes I need. The probes are highly consistent with bright signals allowing easy scoring of results.
Dr. Eric Crawford
Senior Director, Genetics Associates Inc., USA
The quality and reproducibility of results using the CytoCell kit has been vital in accurately detecting co-deletions in our glioma investigations. We now have a cost-effective test that we can rely on that is also easy to use and interpret. We've been consistently impressed with this kit - not to mention the support offered by OGT's customer service, and have completely transitioned over to CytoCell probes.
Gavin Cuthbert, FRCPath
Head of Cancer Cytogenetics, Northern Genetics Servce, Newcastle, UK
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